Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ubr4Ubiquitin protein ligase E3 component n-recognin 4. (5143 aa)    
Predicted Functional Partners:
kcmf1
Potassium channel modulatory factor 1.
    
 
 0.931
LOC105354713
ZZ-type domain-containing protein.
    
 
 0.931
huwe1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
   
 
 0.829
abhd10
Transgelin 3b.
    
   0.765
LOC101171648
Nipsnap homolog 3A (C. elegans).
    
   0.761
exosc3
Exosome component 3.
      
 0.756
ubr2
E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
   
  
 0.742
ubxn7
UBX domain protein 7.
   
   0.728
mrto4
Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.
      
 0.716
emc1
ER membrane protein complex subunit 1.
      
 0.714
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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