six2 protein (Oryzias latipes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

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co-expression

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gene co-occurrence

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[Homology]

Score

six2

SIX homeobox 2a. (290 aa)

Predicted Functional Partners:

eya1

0.828

LOC100049216

0.678

eya4

0.671

LOC101169441

0.671

pax2

0.525

LOC101173867

0.514

hoxc6

0.499

sall1

0.492

rab27b

0.473

dach

0.468

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100049216	dach	ENSORLP00000011778	ENSORLP00000014055	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Ski_Sno domain-containing protein.	0.646
LOC100049216	six2	ENSORLP00000011778	ENSORLP00000005562	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2a.	0.678
LOC101169441	dach	ENSORLP00000041634	ENSORLP00000014055	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Ski_Sno domain-containing protein.	0.646
LOC101169441	six2	ENSORLP00000041634	ENSORLP00000005562	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2a.	0.671
LOC101173867	six2	ENSORLP00000005695	ENSORLP00000005562	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	SIX homeobox 2a.	0.514
dach	LOC100049216	ENSORLP00000014055	ENSORLP00000011778	Ski_Sno domain-containing protein.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.646
dach	LOC101169441	ENSORLP00000014055	ENSORLP00000041634	Ski_Sno domain-containing protein.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.646
dach	eya1	ENSORLP00000014055	ENSORLP00000045154	Ski_Sno domain-containing protein.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.757
dach	eya4	ENSORLP00000014055	ENSORLP00000028671	Ski_Sno domain-containing protein.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.646
dach	six2	ENSORLP00000014055	ENSORLP00000005562	Ski_Sno domain-containing protein.	SIX homeobox 2a.	0.468
eya1	dach	ENSORLP00000045154	ENSORLP00000014055	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Ski_Sno domain-containing protein.	0.757
eya1	pax2	ENSORLP00000045154	ENSORLP00000038259	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Paired box 2b.	0.650
eya1	six2	ENSORLP00000045154	ENSORLP00000005562	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2a.	0.828
eya4	dach	ENSORLP00000028671	ENSORLP00000014055	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Ski_Sno domain-containing protein.	0.646
eya4	six2	ENSORLP00000028671	ENSORLP00000005562	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2a.	0.671
hoxc6	six2	ENSORLP00000009951	ENSORLP00000005562	Homeobox C6a.	SIX homeobox 2a.	0.499
pax2	eya1	ENSORLP00000038259	ENSORLP00000045154	Paired box 2b.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.650
pax2	six2	ENSORLP00000038259	ENSORLP00000005562	Paired box 2b.	SIX homeobox 2a.	0.525
rab27b	six2	ENSORLP00000036287	ENSORLP00000005562	RAB27B, member RAS oncogene family.	SIX homeobox 2a.	0.473
sall1	six2	ENSORLP00000017337	ENSORLP00000005562	Spalt-like transcription factor 1a.	SIX homeobox 2a.	0.492