Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
brca1Uncharacterized protein. (1292 aa)    
Predicted Functional Partners:
babam1
BRISC and BRCA1 A complex member 1.
    
 0.999
Brcc3
BRCA1/BRCA2-containing complex, subunit 3.
    
 0.999
bard1
BRCA1 associated RING domain 1.
   
 0.999
rad51
DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]
   
 0.999
brca2
BRCA2 DNA repair associated.
   
 0.999
Rbbp8
SAE2 domain-containing protein.
    
 0.999
palb2
PALB2_WD40 domain-containing protein.
   
 0.999
babam2
BRISC and BRCA1 A complex member 2.
    
 0.998
ENSORLP00000027619
TAN domain-containing protein.
    
 0.998
tp53bp1
Tumor protein p53 binding protein, 1.
    
 0.998
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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