Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (604 aa)    
Predicted Functional Partners:
smpd2
Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase).
     
 0.986
smpd3
Sphingomyelin phosphodiesterase 3, neutral.
     
 0.983
smpd4
Sphingomyelin phosphodiesterase 4.
     
 0.971
sgms1
Zgc:91976.
     
 0.958
sgms2
Sphingomyelin synthase 2a.
     
 0.958
LOC101170793
PAP2_C domain-containing protein.
     
 0.958
galc
Galactosylceramidase b.
     
 0.955
ugcg
UDP-glucose ceramide glucosyltransferase.
     
 0.948
gba
Glucosylceramidase.
   
 
 0.945
asah1
N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family.
   
 0.942
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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