dhfr protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

dhfr

Dihydrofolate reductase. (189 aa)

Predicted Functional Partners:

tyms

0.999

fpgs

0.993

shmt1

0.980

gart

0.973

mthfd1l

0.973

SHMT2

0.970

shmt2

0.970

qdpr

0.967

amt

0.963

atic

0.957

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHMT2	amt	ENSORLP00000004789	ENSORLP00000030030	Serine hydroxymethyltransferase 2.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.978
SHMT2	atic	ENSORLP00000004789	ENSORLP00000033190	Serine hydroxymethyltransferase 2.	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	0.984
SHMT2	dhfr	ENSORLP00000004789	ENSORLP00000006371	Serine hydroxymethyltransferase 2.	Dihydrofolate reductase.	0.970
SHMT2	fpgs	ENSORLP00000004789	ENSORLP00000022891	Serine hydroxymethyltransferase 2.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.783
SHMT2	gart	ENSORLP00000004789	ENSORLP00000007887	Serine hydroxymethyltransferase 2.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.999
SHMT2	mthfd1l	ENSORLP00000004789	ENSORLP00000018107	Serine hydroxymethyltransferase 2.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.969
SHMT2	shmt1	ENSORLP00000004789	ENSORLP00000017275	Serine hydroxymethyltransferase 2.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.901
SHMT2	shmt2	ENSORLP00000004789	ENSORLP00000006970	Serine hydroxymethyltransferase 2.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.901
SHMT2	tyms	ENSORLP00000004789	ENSORLP00000013877	Serine hydroxymethyltransferase 2.	Thymidylate synthetase.	0.976
amt	SHMT2	ENSORLP00000030030	ENSORLP00000004789	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Serine hydroxymethyltransferase 2.	0.978
amt	atic	ENSORLP00000030030	ENSORLP00000033190	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	0.962
amt	dhfr	ENSORLP00000030030	ENSORLP00000006371	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Dihydrofolate reductase.	0.963
amt	fpgs	ENSORLP00000030030	ENSORLP00000022891	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.	0.672
amt	gart	ENSORLP00000030030	ENSORLP00000007887	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.978
amt	mthfd1l	ENSORLP00000030030	ENSORLP00000018107	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	0.945
amt	shmt1	ENSORLP00000030030	ENSORLP00000017275	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.978
amt	shmt2	ENSORLP00000030030	ENSORLP00000006970	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.978
amt	tyms	ENSORLP00000030030	ENSORLP00000013877	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Thymidylate synthetase.	0.971
atic	SHMT2	ENSORLP00000033190	ENSORLP00000004789	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Serine hydroxymethyltransferase 2.	0.984
atic	amt	ENSORLP00000033190	ENSORLP00000030030	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.962