STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dot1lHistone-lysine N-methyltransferase, H3 lysine-79 specific. (1578 aa)    
Predicted Functional Partners:
tfb2m
rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
      
 0.914
med8
Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
      
 0.914
sirt1
Deacetylase sirtuin-type domain-containing protein.
    
 
 0.881
LOC101156654
Ets variant 7.
      
 0.864
mllt6
MLLT6, PHD finger containing.
    
 
 0.856
mllt10
MLLT10 histone lysine methyltransferase DOT1L cofactor.
    
 
 0.856
setd2
SET domain containing 2, histone lysine methyltransferase.
   
 
 0.854
mllt1
MLLT1 super elongation complex subunit a.
   
 
 0.847
mllt3
MLLT3 super elongation complex subunit.
   
 
 0.847
setd1b
SET domain containing 1B, histone lysine methyltransferase a.
   
 
 0.795
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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