Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
LOC101157952Mitogen-activated protein kinase. (420 aa)    
Predicted Functional Partners:
LOC101160956
JunE proto-oncogene, AP-1 transcription factor subunit.
   
 0.998
ENSORLP00000032968
Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.
   
 0.998
map2k4
Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily.
   
0.996
c-fos
BZIP domain-containing protein.
   
 0.996
LOC101161098
Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.
   
0.996
LOC101164997
Mitogen-activated protein kinase.
  
0.995
LOC101168799
Mitogen-activated protein kinase.
  
0.995
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 0.994
map2k7
Mitogen-activated protein kinase kinase 7.
   
0.992
LOC101165887
ETS transcription factor ELK1.
    
 0.979
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.