STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dph22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (492 aa)    
Predicted Functional Partners:
LOC111946403
DPH-type MB domain-containing protein.
   
 0.999
dph1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.
   
 0.998
dph5
Diphthamide biosynthesis 5.
   
 0.975
LOC101171982
Tr-type G domain-containing protein.
    
 0.940
EEF2
Eukaryotic translation elongation factor 2b.
    
 0.940
dph7
Diphthamide biosynthesis 7.
      
 0.902
dnajc24
Uncharacterized protein.
   
 
 0.811
ddx56
DEAD (Asp-Glu-Ala-Asp) box helicase 56.
   
 
 0.749
atp6v0b
ATPase H+ transporting V0 subunit b; Belongs to the V-ATPase proteolipid subunit family.
      
 0.746
rrp9
Ribosomal RNA processing 9, U3 small nucleolar RNA binding protein.
   
    0.725
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.