nae1 protein (Oryzias latipes) - STRING interaction network

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nae1

NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)

Predicted Functional Partners:

LOC101162521

0.993

UBA3

0.993

ENSORLP00000027520

0.971

ENSORLP00000045836

0.971

ube2m

0.923

ube2f

0.923

cul1

0.899

rpl10a

0.891

cacul1

0.819

trip12

0.815

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000027520	LOC101162521	ENSORLP00000027520	ENSORLP00000009971	Ubiquitin-like domain-containing protein.	Ubiquitin-like modifier activating enzyme 3.	0.937
ENSORLP00000027520	UBA3	ENSORLP00000027520	ENSORLP00000016993	Ubiquitin-like domain-containing protein.	Ubiquitin like modifier activating enzyme 3.	0.937
ENSORLP00000027520	cacul1	ENSORLP00000027520	ENSORLP00000017148	Ubiquitin-like domain-containing protein.	CDK2 associated cullin domain 1; Belongs to the cullin family.	0.889
ENSORLP00000027520	cul1	ENSORLP00000027520	ENSORLP00000003749	Ubiquitin-like domain-containing protein.	Cullin 1b; Belongs to the cullin family.	0.982
ENSORLP00000027520	nae1	ENSORLP00000027520	ENSORLP00000006837	Ubiquitin-like domain-containing protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.971
ENSORLP00000027520	rpl10a	ENSORLP00000027520	ENSORLP00000008283	Ubiquitin-like domain-containing protein.	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	0.473
ENSORLP00000027520	trip12	ENSORLP00000027520	ENSORLP00000014712	Ubiquitin-like domain-containing protein.	Thyroid hormone receptor interactor 12.	0.873
ENSORLP00000027520	ube2f	ENSORLP00000027520	ENSORLP00000045631	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme E2F (putative); Belongs to the ubiquitin-conjugating enzyme family.	0.921
ENSORLP00000027520	ube2m	ENSORLP00000027520	ENSORLP00000029012	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.921
ENSORLP00000045836	LOC101162521	ENSORLP00000045836	ENSORLP00000009971	Ubiquitin-like domain-containing protein.	Ubiquitin-like modifier activating enzyme 3.	0.937
ENSORLP00000045836	UBA3	ENSORLP00000045836	ENSORLP00000016993	Ubiquitin-like domain-containing protein.	Ubiquitin like modifier activating enzyme 3.	0.937
ENSORLP00000045836	cacul1	ENSORLP00000045836	ENSORLP00000017148	Ubiquitin-like domain-containing protein.	CDK2 associated cullin domain 1; Belongs to the cullin family.	0.889
ENSORLP00000045836	cul1	ENSORLP00000045836	ENSORLP00000003749	Ubiquitin-like domain-containing protein.	Cullin 1b; Belongs to the cullin family.	0.982
ENSORLP00000045836	nae1	ENSORLP00000045836	ENSORLP00000006837	Ubiquitin-like domain-containing protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.971
ENSORLP00000045836	rpl10a	ENSORLP00000045836	ENSORLP00000008283	Ubiquitin-like domain-containing protein.	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	0.473
ENSORLP00000045836	trip12	ENSORLP00000045836	ENSORLP00000014712	Ubiquitin-like domain-containing protein.	Thyroid hormone receptor interactor 12.	0.873
ENSORLP00000045836	ube2f	ENSORLP00000045836	ENSORLP00000045631	Ubiquitin-like domain-containing protein.	Ubiquitin-conjugating enzyme E2F (putative); Belongs to the ubiquitin-conjugating enzyme family.	0.921
ENSORLP00000045836	ube2m	ENSORLP00000045836	ENSORLP00000029012	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.921
LOC101162521	ENSORLP00000027520	ENSORLP00000009971	ENSORLP00000027520	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like domain-containing protein.	0.937
LOC101162521	ENSORLP00000045836	ENSORLP00000009971	ENSORLP00000045836	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like domain-containing protein.	0.937

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