Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
Mdh2Malate dehydrogenase. (364 aa)    
Predicted Functional Partners:
got2
Aspartate aminotransferase.
   
 0.999
cs
Citrate synthase; Belongs to the citrate synthase family.
  
 0.999
fh
Fumarate hydratase.
  
 0.998
aco2
Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.
  
 0.996
LOC101173617
Malate synthase-like.
  
 0.994
atp5f1b
ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
 0.993
GOT1
Aspartate aminotransferase.
   
 0.988
got1
Aspartate aminotransferase.
   
 0.988
suclg1
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.
  
 0.983
LOC101160076
ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.
  
 0.982
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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