bf/c2 protein (Oryzias latipes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Score

bf/c2

Bf/C2 protein; Belongs to the peptidase S1 family. (754 aa)

Predicted Functional Partners:

H2M6Q1_ORYLA

0.740

LOC101169766

0.739

LOC101167637

0.728

cfp

0.709

c9

0.699

c5

0.684

LOC101170893

0.676

LOC101171566

0.653

ENSORLP00000034462

0.653

cfi

0.614

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000034462	bf/c2	ENSORLP00000034462	ENSORLP00000007296	Uncharacterized protein; Belongs to the multicopper oxidase family.	Bf/C2 protein; Belongs to the peptidase S1 family.	0.653
H2M6Q1_ORYLA	LOC101167637	ENSORLP00000014148	ENSORLP00000019627	NTR domain-containing protein.	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	0.512
H2M6Q1_ORYLA	bf/c2	ENSORLP00000014148	ENSORLP00000007296	NTR domain-containing protein.	Bf/C2 protein; Belongs to the peptidase S1 family.	0.740
H2M6Q1_ORYLA	c5	ENSORLP00000014148	ENSORLP00000021960	NTR domain-containing protein.	Uncharacterized protein.	0.488
H2M6Q1_ORYLA	c9	ENSORLP00000014148	ENSORLP00000003701	NTR domain-containing protein.	Complement component 9.	0.419
H2M6Q1_ORYLA	cfi	ENSORLP00000014148	ENSORLP00000002940	NTR domain-containing protein.	Complement factor I; Belongs to the peptidase S1 family.	0.677
H2M6Q1_ORYLA	cfp	ENSORLP00000014148	ENSORLP00000007326	NTR domain-containing protein.	Uncharacterized protein.	0.503
LOC101167637	H2M6Q1_ORYLA	ENSORLP00000019627	ENSORLP00000014148	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	NTR domain-containing protein.	0.512
LOC101167637	LOC101169766	ENSORLP00000019627	ENSORLP00000007436	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	0.536
LOC101167637	LOC101170893	ENSORLP00000019627	ENSORLP00000024945	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	Complement component c3b, tandem duplicate 2.	0.518
LOC101167637	bf/c2	ENSORLP00000019627	ENSORLP00000007296	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	Bf/C2 protein; Belongs to the peptidase S1 family.	0.728
LOC101167637	c5	ENSORLP00000019627	ENSORLP00000021960	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.757
LOC101167637	c9	ENSORLP00000019627	ENSORLP00000003701	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	Complement component 9.	0.495
LOC101167637	cfi	ENSORLP00000019627	ENSORLP00000002940	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	Complement factor I; Belongs to the peptidase S1 family.	0.598
LOC101167637	cfp	ENSORLP00000019627	ENSORLP00000007326	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	Uncharacterized protein.	0.691
LOC101169766	LOC101167637	ENSORLP00000007436	ENSORLP00000019627	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	0.536
LOC101169766	bf/c2	ENSORLP00000007436	ENSORLP00000007296	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	Bf/C2 protein; Belongs to the peptidase S1 family.	0.739
LOC101169766	cfi	ENSORLP00000007436	ENSORLP00000002940	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	Complement factor I; Belongs to the peptidase S1 family.	0.436
LOC101169766	cfp	ENSORLP00000007436	ENSORLP00000007326	Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1; Belongs to the serpin family.	Uncharacterized protein.	0.410
LOC101170893	LOC101167637	ENSORLP00000024945	ENSORLP00000019627	Complement component c3b, tandem duplicate 2.	Si:ch1073-280e3.1; Belongs to the peptidase S1 family.	0.518

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

10

PPI enrichment p-value:

1.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031204

Post-translational protein targeting to membrane, translocation

4 of 6

3.28

4.69

2.97e-09

GO:0045047

Protein targeting to ER

5 of 28

2.7

4.55

2.49e-09

GO:0006612

Protein targeting to membrane

5 of 51

2.44

4.16

6.70e-09

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

4 of 17

2.82

3.98

4.00e-08

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

3 of 5

3.23

3.36

8.22e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043022

Ribosome binding

4 of 61

2.27

2.52

1.25e-05

GO:0008320

Protein transmembrane transporter activity

2 of 13

2.64

1.13

0.0088

GO:0019838

Growth factor binding

2 of 18

2.5

1.12

0.0088

GO:0042562

Hormone binding

2 of 26

2.34

1.04

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140534

Endoplasmic reticulum protein-containing complex

7 of 74

2.43

6.44

3.60e-14

GO:0071256

Translocon complex

4 of 4

3.45

5.6

7.00e-11

GO:0005789

Endoplasmic reticulum membrane

11 of 581

1.73

4.5

1.14e-16

GO:0005784

Sec61 translocon complex

3 of 3

3.45

4.0

5.84e-08

GO:0008250

Oligosaccharyltransferase complex

3 of 10

2.93

3.38

6.25e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31634

Oligosaccharyltransferase complex, and Post-translational protein targeting to membrane, translocation

10 of 24

3.07

13.33

2.63e-26

CL:31636

Oligosaccharyltransferase complex, and Translocon-associated

8 of 18

3.1

10.68

7.22e-21

CL:31661

Mixed, incl. Sec61beta family, and Translocon-associated

5 of 5

3.45

6.95

2.28e-13

CL:31638

Oligosaccharyltransferase complex

3 of 11

2.89

5.12e-06

CL:31641

Oligosaccharyltransferase complex

2 of 5

3.05

1.68

0.00093

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

10 of 303

1.97

5.9

1.62e-17

map03060

Protein export

4 of 39

2.46

3.66

8.41e-08

map04145

Phagosome

4 of 151

1.87

2.29

1.03e-05

map00510

N-Glycan biosynthesis

2 of 71

1.9

0.99

0.0120

map00513

Various types of N-glycan biosynthesis

2 of 80

1.85

0.98

0.0121

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

6 of 115

2.17

4.09

1.80e-09

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

3 of 17

2.7

2.59

1.62e-05

MAP-72766

Translation

6 of 322

1.72

2.56

3.76e-07

MAP-9609507

Protein localization

3 of 210

1.61

0.87

0.0163

MAP-392499

Metabolism of proteins

6 of 2399

0.85

0.54

0.0181

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071256

Translocon complex

5 of 6

3.37

6.9

2.69e-13

GOCC:0005789

Endoplasmic reticulum membrane

9 of 199

2.11

6.09

7.43e-16

GOCC:0005784

Sec61 translocon complex

4 of 5

3.35

5.38

1.69e-10

GOCC:0005783

Endoplasmic reticulum

10 of 354

1.9

5.24

5.63e-16

GOCC:0098796

Membrane protein complex

8 of 516

1.64

3.15

1.69e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

4 of 61

2.27

2.93

1.65e-06

KW-0811

Translocation

2 of 13

2.64

1.72

0.00069

KW-1133

Transmembrane helix

10 of 6441

0.64

0.55

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03911

Sec61beta family

2 of 2

3.45

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030671

Protein transport Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

IPR016482

Protein transport protein SecG/Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

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