Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
sigirrSingle immunoglobulin and toll-interleukin 1 receptor (TIR) domain. (520 aa)    
Predicted Functional Partners:
Unc79
Uncharacterized protein.
    
 0.683
LOC101169418
Fibrinogen C-terminal domain-containing protein.
   
 0.659
LOC101165534
Fibrinogen C-terminal domain-containing protein.
   
 0.659
LOC101161869
Fibrinogen C-terminal domain-containing protein.
   
 0.659
tada3
Transcriptional adaptor 3 (NGG1 homolog, yeast)-like.
    
 0.605
myd88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.
    
 0.602
ruvbl1
RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.
    
 0.567
pik3ap1
Phosphoinositide-3-kinase adaptor protein 1.
      
 0.561
chst2
Sulfotransferase; Belongs to the sulfotransferase 1 family.
      
 0.535
traf6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.533
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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