Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
mmp16ZnMc domain-containing protein. (612 aa)    
Predicted Functional Partners:
H2ME57_ORYLA
V-set immunoregulatory receptor.
      
 0.719
timp-2b
Tissue inhibitor of metalloproteinase-2b.
   
 0.704
timp2
Tissue inhibitor of metalloproteinase-2a.
   
 0.671
timp3
NTR domain-containing protein.
   
 0.666
LOC101164922
Cathepsin K; Belongs to the peptidase C1 family.
   
 0.594
timp4
TIMP metallopeptidase inhibitor 4, tandem duplicate 2.
    
 0.588
LOC100049240
Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.
    
 0.530
furin
Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family.
    
 0.530
mmp2
Uncharacterized protein.
   
 0.463
LOC101156669
Matrix metallopeptidase 13b.
   
 0.462
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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