STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Cooccurrence
Coexpression
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[Homology]
Score
hps5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1110 aa)    
Predicted Functional Partners:
HPS6
HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.
    
 0.997
hps3
HPS3 biogenesis of lysosomal organelles complex 2 subunit 1.
   
 
 0.990
hps4
HPS4 biogenesis of lysosomal organelles complex 3 subunit 2.
     
 0.942
bloc1s3
Biogenesis of lysosomal organelles complex-1, subunit 3.
     
 0.897
dtnbp1
Dystrobrevin binding protein 1b.
     
 0.892
bloc1s6
Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]
     
 0.858
ggcx
Gamma-glutamyl carboxylase.
      
 0.754
frmd7
FERM domain-containing protein.
      
 0.702
bloc1s5
Biogenesis of lysosomal organelles complex-1, subunit 5, muted.
     
 0.675
ap3d1
Adaptor related protein complex 3 subunit delta 1.
    
 
 0.667
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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