STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101168864P53-induced death domain protein 1. (1004 aa)    
Predicted Functional Partners:
casp2
Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.
    
 0.999
LOC101164618
CASP2 and RIPK1 domain containing adaptor with death domain.
    
 0.999
fadd
Uncharacterized protein.
   
 0.869
ENSORLP00000027619
TAN domain-containing protein.
    
 0.836
Atm
Uncharacterized protein.
    
 0.827
ripk1
Receptor (TNFRSF)-interacting serine-threonine kinase 1, like.
   
 0.812
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 0.779
LOC101170553
NME/NM23 family member 8; Belongs to the NDK family.
   
 0.767
plk4
Polo-like kinase 4 (Drosophila).
    
 0.746
Wdr90
WD_REPEATS_REGION domain-containing protein.
   
 0.745
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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