Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smpd2Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase). (442 aa)    
Predicted Functional Partners:
smpd3
Sphingomyelin phosphodiesterase 3, neutral.
     
 0.993
smpd4
Sphingomyelin phosphodiesterase 4.
     
 0.989
smpd1
Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.
     
 0.986
ugcg
UDP-glucose ceramide glucosyltransferase.
     
 0.973
sgms1
Zgc:91976.
     
 0.947
gba2
Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.
     
 0.947
sgms2
Sphingomyelin synthase 2a.
     
 0.947
LOC101170793
PAP2_C domain-containing protein.
     
 0.947
LOC101160838
Sphingomyelin phosphodiesterase 5.
     
 0.944
degs1
Delta(4)-desaturase, sphingolipid 1.
     
 0.942
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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