STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)    
Predicted Functional Partners:
mdm2
MDM2 proto-oncogene.
   
 0.999
mdm4
MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.
   
 0.999
Atm
Uncharacterized protein.
   
 0.996
LOC101160197
E1A binding protein p300 a.
    
 0.995
sirt1
Deacetylase sirtuin-type domain-containing protein.
    
 0.995
LOC101168870
E1A binding protein p300 b.
    
 0.995
chek2
Checkpoint kinase 2.
    
 0.995
adcy9
CREB binding protein b.
    
 0.994
LOC101163392
CREB binding protein a.
    
 0.994
chek1
Checkpoint kinase 1; Belongs to the protein kinase superfamily.
    
 0.992
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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