tp53 protein (Oryzias latipes) - STRING interaction network

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tp53

Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family. (352 aa)

Predicted Functional Partners:

chek1

0.999

sirt1

0.999

ENSORLP00000027619

0.999

chek2

0.999

mdm2

0.999

mdm4

0.999

prkdc

0.998

LOC101160197

0.997

LOC101168870

0.997

brca1

0.996

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000027619	brca1	ENSORLP00000027619	ENSORLP00000005763	TAN domain-containing protein.	Uncharacterized protein.	0.998
ENSORLP00000027619	chek1	ENSORLP00000027619	ENSORLP00000007199	TAN domain-containing protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.997
ENSORLP00000027619	chek2	ENSORLP00000027619	ENSORLP00000032936	TAN domain-containing protein.	Checkpoint kinase 2.	0.999
ENSORLP00000027619	mdm2	ENSORLP00000027619	ENSORLP00000034706	TAN domain-containing protein.	MDM2 proto-oncogene.	0.964
ENSORLP00000027619	mdm4	ENSORLP00000027619	ENSORLP00000035882	TAN domain-containing protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.887
ENSORLP00000027619	prkdc	ENSORLP00000027619	ENSORLP00000006867	TAN domain-containing protein.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.867
ENSORLP00000027619	sirt1	ENSORLP00000027619	ENSORLP00000017142	TAN domain-containing protein.	Deacetylase sirtuin-type domain-containing protein.	0.465
ENSORLP00000027619	tp53	ENSORLP00000027619	ENSORLP00000008031	TAN domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.999
LOC101160197	brca1	ENSORLP00000003103	ENSORLP00000005763	E1A binding protein p300 a.	Uncharacterized protein.	0.917
LOC101160197	mdm2	ENSORLP00000003103	ENSORLP00000034706	E1A binding protein p300 a.	MDM2 proto-oncogene.	0.939
LOC101160197	mdm4	ENSORLP00000003103	ENSORLP00000035882	E1A binding protein p300 a.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.510
LOC101160197	prkdc	ENSORLP00000003103	ENSORLP00000006867	E1A binding protein p300 a.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.465
LOC101160197	sirt1	ENSORLP00000003103	ENSORLP00000017142	E1A binding protein p300 a.	Deacetylase sirtuin-type domain-containing protein.	0.883
LOC101160197	tp53	ENSORLP00000003103	ENSORLP00000008031	E1A binding protein p300 a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.997
LOC101168870	brca1	ENSORLP00000032567	ENSORLP00000005763	E1A binding protein p300 b.	Uncharacterized protein.	0.917
LOC101168870	mdm2	ENSORLP00000032567	ENSORLP00000034706	E1A binding protein p300 b.	MDM2 proto-oncogene.	0.939
LOC101168870	mdm4	ENSORLP00000032567	ENSORLP00000035882	E1A binding protein p300 b.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.510
LOC101168870	prkdc	ENSORLP00000032567	ENSORLP00000006867	E1A binding protein p300 b.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.465
LOC101168870	sirt1	ENSORLP00000032567	ENSORLP00000017142	E1A binding protein p300 b.	Deacetylase sirtuin-type domain-containing protein.	0.883
LOC101168870	tp53	ENSORLP00000032567	ENSORLP00000008031	E1A binding protein p300 b.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.	0.997

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