STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101164703Programmed cell death 4a. (462 aa)    
Predicted Functional Partners:
mtap
S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
      
 0.793
eif4a2
Eukaryotic translation initiation factor 4A, isoform 2; Belongs to the DEAD box helicase family.
   
 
 0.721
LOC101155548
Eukaryotic translation initiation factor 4A1B; Belongs to the DEAD box helicase family.
   
 
 0.721
Topors
Topoisomerase I binding, arginine/serine-rich a.
      
 0.668
fbxw11
F-box and WD repeat domain containing 11a.
    
 
 0.667
eif4a3
Eukaryotic translation initiation factor 4A3.
   
 
 0.662
cxxc4
CXXC finger 4.
      
 0.656
eif3a
Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
    
 
 0.581
cdkn2b
Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4).
      
 0.534
tet2
Tet methylcytosine dioxygenase 2.
      
 0.527
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.