STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
psenenPresenilin enhancer, gamma-secretase subunit. (101 aa)    
Predicted Functional Partners:
NCSTN
Nicastrin.
    
 0.999
LOC101159650
APH1B gamma secretase subunit.
    
 0.999
LOC101154844
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.998
psen2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.997
LOC101172288
Amyloid beta (A4) precursor protein b.
    
 0.881
notch1
Notch receptor 1b.
    
 0.871
LOC101171596
Notch receptor 1a.
    
 0.871
APP
Amyloid beta precursor protein.
    
 0.855
LOC101162450
Notch receptor 3.
    
 0.786
aplp2
Amyloid beta (A4) precursor-like protein 2.
    
 0.719
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
Server load: medium (44%) [HD]