STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
edaEctodysplasin A; Belongs to the tumor necrosis factor family. (364 aa)    
Predicted Functional Partners:
edar
Tumor necrosis factor receptor superfamily member EDAR; Receptor for EDA (By similarity). May mediate the activation of NF-kappa-B and JNK.
    
 0.997
tnfrsf19
Tumor necrosis factor receptor superfamily, member 19.
     
 0.794
ENSORLP00000041652
TNFR-Cys domain-containing protein.
     
 0.794
edaradd
EDAR-associated death domain.
     
 0.771
nanos2
Nanos-type domain-containing protein; Belongs to the nanos family.
     
 0.502
nanos3
NANOS3; Belongs to the nanos family.
     
 0.502
nanos1a
NANOS1A; Belongs to the nanos family.
     
 0.502
ENSORLP00000026634
Uncharacterized protein.
      
 0.501
pln
Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.
    
   0.497
LRRC9
Leucine rich repeat containing 9.
      
 0.454
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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