STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
txndc5Thioredoxin domain containing 5; Belongs to the protein disulfide isomerase family. (413 aa)    
Predicted Functional Partners:
LOC101167922
Endoplasmic reticulum oxidoreductase alpha.
   
 0.958
ero1b
Endoplasmic reticulum oxidoreductase beta.
   
 0.958
bloc1s1
Biogenesis of lysosomal organelles complex-1, subunit 1.
     
 0.953
hspa5
Uncharacterized protein; Belongs to the heat shock protein 70 family.
   
 0.936
LOC101166157
Peroxiredoxin 4.
  
 0.930
bloc1s6
Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]
   
 
  0.851
hsp90b1
Heat shock protein 90, beta (grp94), member 1.
   
 0.789
bloc1s3
Biogenesis of lysosomal organelles complex-1, subunit 3.
     
  0.772
gmppb
GDP-mannose pyrophosphorylase B.
  
 
 0.734
dnajc3
DnaJ (Hsp40) homolog, subfamily C, member 3a.
   
 0.695
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.