proc protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

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Experiments

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[Homology]

Score

proc

Protein C (inactivator of coagulation factors Va and VIIIa), a. (436 aa)

Predicted Functional Partners:

LOC101170246

0.991

ggcx

0.972

pros1

0.954

LOC101174928

0.934

LOC101166425

0.934

stil

0.930

serpind1

0.885

LOC100049240

0.771

furin

0.771

fga

0.760

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100049240	LOC101170246	ENSORLP00000011461	ENSORLP00000033975	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.806
LOC100049240	furin	ENSORLP00000011461	ENSORLP00000026927	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family.	0.901
LOC100049240	proc	ENSORLP00000011461	ENSORLP00000008456	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	Protein C (inactivator of coagulation factors Va and VIIIa), a.	0.771
LOC100049240	pros1	ENSORLP00000011461	ENSORLP00000006077	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	Protein S.	0.751
LOC101166425	LOC101170246	ENSORLP00000030665	ENSORLP00000033975	Coagulation factor V; Belongs to the multicopper oxidase family.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.949
LOC101166425	fga	ENSORLP00000030665	ENSORLP00000003045	Coagulation factor V; Belongs to the multicopper oxidase family.	Fibrinogen alpha chain.	0.497
LOC101166425	proc	ENSORLP00000030665	ENSORLP00000008456	Coagulation factor V; Belongs to the multicopper oxidase family.	Protein C (inactivator of coagulation factors Va and VIIIa), a.	0.934
LOC101166425	pros1	ENSORLP00000030665	ENSORLP00000006077	Coagulation factor V; Belongs to the multicopper oxidase family.	Protein S.	0.894
LOC101166425	serpind1	ENSORLP00000030665	ENSORLP00000002789	Coagulation factor V; Belongs to the multicopper oxidase family.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.604
LOC101166425	stil	ENSORLP00000030665	ENSORLP00000017607	Coagulation factor V; Belongs to the multicopper oxidase family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.721
LOC101170246	LOC100049240	ENSORLP00000033975	ENSORLP00000011461	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Furin (paired basic amino acid cleaving enzyme) a; Belongs to the peptidase S8 family.	0.806
LOC101170246	LOC101166425	ENSORLP00000033975	ENSORLP00000030665	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor V; Belongs to the multicopper oxidase family.	0.949
LOC101170246	LOC101174928	ENSORLP00000033975	ENSORLP00000003708	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor VIII, procoagulant component; Belongs to the multicopper oxidase family.	0.949
LOC101170246	fga	ENSORLP00000033975	ENSORLP00000003045	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Fibrinogen alpha chain.	0.998
LOC101170246	furin	ENSORLP00000033975	ENSORLP00000026927	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Furin (paired basic amino acid cleaving enzyme) b; Belongs to the peptidase S8 family.	0.806
LOC101170246	ggcx	ENSORLP00000033975	ENSORLP00000011804	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Gamma-glutamyl carboxylase.	0.988
LOC101170246	proc	ENSORLP00000033975	ENSORLP00000008456	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein C (inactivator of coagulation factors Va and VIIIa), a.	0.991
LOC101170246	pros1	ENSORLP00000033975	ENSORLP00000006077	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein S.	0.499
LOC101170246	serpind1	ENSORLP00000033975	ENSORLP00000002789	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Serpin peptidase inhibitor, clade D (heparin cofactor), member 1; Belongs to the serpin family.	0.998
LOC101170246	stil	ENSORLP00000033975	ENSORLP00000017607	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.999