Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cyp11aCholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (517 aa)    
Predicted Functional Partners:
3bhsd
3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family.
   
 0.971
cyp17
Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction; Belongs to the cytochrome P450 family.
  
0.959
LOC101173499
Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family.
  
 
0.956
cyp17a2
Cytochrome P450 family 17 polypeptide 2; Belongs to the cytochrome P450 family.
  
0.950
LOC101157155
Cytochrome P450, family 21, subfamily A, polypeptide 2; Belongs to the cytochrome P450 family.
  
0.945
sts
Steroid sulfatase (microsomal), isozyme S.
     
 0.922
LOC101174401
Sulfotransferase; Belongs to the sulfotransferase 1 family.
     
 0.908
LOC111948904
Sulfotransferase; Belongs to the sulfotransferase 1 family.
     
 0.908
LOC110016637
Sulfotransferase; Belongs to the sulfotransferase 1 family.
     
 0.908
dhcr7
7-dehydrocholesterol reductase.
    
 0.876
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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