Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
twist1-2Basic helix-loop-helix transcription factor twist. (168 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 
 0.759
snai2
Snail family zinc finger 2.
   
 
 0.737
tcf12
Transcription factor 12.
    
 
 0.697
fbxw11
F-box and WD repeat domain containing 11a.
    
 
 0.663
LOC101161725
BHLH domain-containing protein.
    
 
 0.638
prrx1
Paired related homeobox 1a.
   
 
 0.637
nmnat3
Nicotinamide-nucleotide adenylyltransferase.
    
   0.617
LOC101174424-2
Nicotinamide-nucleotide adenylyltransferase.
    
   0.617
foxn4
Forkhead box N4.
   
 
 0.613
runx2
Runt-related transcription factor.
    
 0.546
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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