Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
neil1Nei-like DNA glycosylase 1. (413 aa)    
Predicted Functional Partners:
neil3
Nei-like DNA glycosylase 3.
     
 0.994
polb
DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
   
 0.988
pnkp
Polynucleotide kinase 3'-phosphatase.
     
 0.980
ogg1
8-oxoguanine DNA glycosylase.
     
 0.969
nthl1
Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.
      
 0.929
asns
Asparagine synthetase [glutamine-hydrolyzing].
      
 0.910
xrcc1
X-ray repair complementing defective repair in Chinese hamster cells 1.
    
 0.889
LOC101171754
LON peptidase N-terminal domain and ring finger 1.
      
 0.820
lonrf1
LON peptidase N-terminal domain and ring finger 1, like.
      
 0.816
smug1
Single-strand-selective monofunctional uracil-DNA glycosylase 1.
      
 0.808
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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