Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
trpv4Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)    
Predicted Functional Partners:
trpc1
Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.926
trpm7
Transient receptor potential cation channel, subfamily M, member 7.
   
 
 0.824
piezo1
Piezo-type mechanosensitive ion channel component.
      
 0.818
trpa1
Transient receptor potential cation channel, subfamily A, member 1b; Belongs to the transient receptor (TC 1.A.4) family.
     
 0.789
LOC101159200
Transient receptor potential cation channel, subfamily M, member 6.
   
 
 0.714
trpm5
Transient receptor potential cation channel, subfamily M, member 5.
   
 
 0.712
pkd2
Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel. Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades (By similarity). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By simila [...]
      
 0.706
calm3
Calmodulin-A; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
    
 0.685
LOC100049422
Uncharacterized protein; Belongs to the calmodulin family.
    
 0.685
LOC100049419
Calmodulin.
    
 0.685
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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