Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
pou4f2POU domain protein. (426 aa)    
Predicted Functional Partners:
vsx2
Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina (By similarity). Belongs to the paired homeobox family.
   
  
 0.817
atoh7
Atonal bHLH transcription factor 7.
    
 
 0.813
barhl2
BarH-like homeobox 2.
  
  
 0.601
otx2
Homeobox domain-containing protein.
   
  
 0.599
H2LU48_ORYLA
Opsin 4.1.
      
 0.591
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
     
  0.578
lhx3
Uncharacterized protein.
   
 
 0.559
LOC101168145
Visual system homeobox 1 homolog, chx10-like.
   
  
 0.558
neurod1
Neurogenic differentiation factor.
   
  
 0.546
LOC101164593
RRM domain-containing protein.
      
 0.524
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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