drd2 protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

drd2

Dopamine receptor D2a; Belongs to the G-protein coupled receptor 1 family. (467 aa)

Predicted Functional Partners:

LOC105358374

0.949

gnai3

0.949

LOC101157265

0.949

gnai2

0.949

LOC101171193

0.902

LOC101174111

0.757

ncs1

0.732

fat2

0.690

LOC101168199

0.617

LOC101175500

0.617

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101157265	LOC101168199	ENSORLP00000020086	ENSORLP00000004503	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.845
LOC101157265	LOC101171193	ENSORLP00000020086	ENSORLP00000019036	Uncharacterized protein.	Dopamine receptor D2 like; Belongs to the G-protein coupled receptor 1 family.	0.924
LOC101157265	LOC101175500	ENSORLP00000020086	ENSORLP00000009914	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.845
LOC101157265	LOC105358374	ENSORLP00000020086	ENSORLP00000001335	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.579
LOC101157265	drd2	ENSORLP00000020086	ENSORLP00000009423	Uncharacterized protein.	Dopamine receptor D2a; Belongs to the G-protein coupled receptor 1 family.	0.949
LOC101157265	gnai2	ENSORLP00000020086	ENSORLP00000032440	Uncharacterized protein.	Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity).	0.579
LOC101157265	gnai3	ENSORLP00000020086	ENSORLP00000013487	Uncharacterized protein.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.543
LOC101168199	LOC101157265	ENSORLP00000004503	ENSORLP00000020086	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.845
LOC101168199	LOC101175500	ENSORLP00000004503	ENSORLP00000009914	WD_REPEATS_REGION domain-containing protein.	Guanine nucleotide binding protein (G protein), beta polypeptide 2.	0.567
LOC101168199	LOC105358374	ENSORLP00000004503	ENSORLP00000001335	WD_REPEATS_REGION domain-containing protein.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.845
LOC101168199	drd2	ENSORLP00000004503	ENSORLP00000009423	WD_REPEATS_REGION domain-containing protein.	Dopamine receptor D2a; Belongs to the G-protein coupled receptor 1 family.	0.617
LOC101168199	gnai2	ENSORLP00000004503	ENSORLP00000032440	WD_REPEATS_REGION domain-containing protein.	Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity).	0.880
LOC101168199	gnai3	ENSORLP00000004503	ENSORLP00000013487	WD_REPEATS_REGION domain-containing protein.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.845
LOC101171193	LOC101157265	ENSORLP00000019036	ENSORLP00000020086	Dopamine receptor D2 like; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.924
LOC101171193	LOC105358374	ENSORLP00000019036	ENSORLP00000001335	Dopamine receptor D2 like; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b.	0.924
LOC101171193	drd2	ENSORLP00000019036	ENSORLP00000009423	Dopamine receptor D2 like; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D2a; Belongs to the G-protein coupled receptor 1 family.	0.902
LOC101171193	gnai2	ENSORLP00000019036	ENSORLP00000032440	Dopamine receptor D2 like; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division (By similarity).	0.924
LOC101171193	gnai3	ENSORLP00000019036	ENSORLP00000013487	Dopamine receptor D2 like; Belongs to the G-protein coupled receptor 1 family.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.924
LOC101174111	drd2	ENSORLP00000014167	ENSORLP00000009423	Solute carrier family 36 member 1.	Dopamine receptor D2a; Belongs to the G-protein coupled receptor 1 family.	0.757
LOC101174111	fat2	ENSORLP00000014167	ENSORLP00000014138	Solute carrier family 36 member 1.	FAT atypical cadherin 2.	0.848