Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1100 aa)    
Predicted Functional Partners:
pole2
DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.
   
 0.999
pole3
CBFD_NFYB_HMF domain-containing protein.
   
 0.998
pole4
Polymerase (DNA-directed), epsilon 4, accessory subunit.
    
 0.998
pold1
DNA polymerase.
   
0.997
pola1
DNA polymerase.
   
 0.990
pold2
Polymerase (DNA directed), delta 2, regulatory subunit.
   
 0.988
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
  
 0.982
mcm2
DNA helicase; Belongs to the MCM family.
   
 0.964
prim1
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
   
 0.963
pold3
Polymerase (DNA-directed), delta 3, accessory subunit.
   
 0.958
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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