paxip1 protein (Oryzias latipes) - STRING interaction network

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Score

paxip1

PAX interacting (with transcription-activation domain) protein 1. (1107 aa)

Predicted Functional Partners:

pagr1

0.955

rbbp5

0.954

tp53bp1

0.946

ash2l

0.939

rnf8

0.937

ncoa6

0.931

rad50

0.926

brca1

0.925

mre11

0.907

Atm

0.902

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	brca1	ENSORLP00000026266	ENSORLP00000005763	Uncharacterized protein.	Uncharacterized protein.	0.989
Atm	mre11	ENSORLP00000026266	ENSORLP00000009106	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.963
Atm	paxip1	ENSORLP00000026266	ENSORLP00000010077	Uncharacterized protein.	PAX interacting (with transcription-activation domain) protein 1.	0.902
Atm	rad50	ENSORLP00000026266	ENSORLP00000037867	Uncharacterized protein.	RAD50 homolog, double strand break repair protein.	0.978
Atm	rnf8	ENSORLP00000026266	ENSORLP00000015004	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.771
Atm	tp53bp1	ENSORLP00000026266	ENSORLP00000033455	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.982
ash2l	ncoa6	ENSORLP00000044910	ENSORLP00000032744	Ash2 like, histone lysine methyltransferase complex subunit.	Nuclear receptor coactivator 6.	0.995
ash2l	pagr1	ENSORLP00000044910	ENSORLP00000035476	Ash2 like, histone lysine methyltransferase complex subunit.	PAXIP1 associated glutamate-rich protein 1.	0.960
ash2l	paxip1	ENSORLP00000044910	ENSORLP00000010077	Ash2 like, histone lysine methyltransferase complex subunit.	PAX interacting (with transcription-activation domain) protein 1.	0.939
ash2l	rad50	ENSORLP00000044910	ENSORLP00000037867	Ash2 like, histone lysine methyltransferase complex subunit.	RAD50 homolog, double strand break repair protein.	0.406
ash2l	rbbp5	ENSORLP00000044910	ENSORLP00000037669	Ash2 like, histone lysine methyltransferase complex subunit.	Retinoblastoma binding protein 5.	0.999
ash2l	tp53bp1	ENSORLP00000044910	ENSORLP00000033455	Ash2 like, histone lysine methyltransferase complex subunit.	Tumor protein p53 binding protein, 1.	0.762
brca1	Atm	ENSORLP00000005763	ENSORLP00000026266	Uncharacterized protein.	Uncharacterized protein.	0.989
brca1	mre11	ENSORLP00000005763	ENSORLP00000009106	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.995
brca1	paxip1	ENSORLP00000005763	ENSORLP00000010077	Uncharacterized protein.	PAX interacting (with transcription-activation domain) protein 1.	0.925
brca1	rad50	ENSORLP00000005763	ENSORLP00000037867	Uncharacterized protein.	RAD50 homolog, double strand break repair protein.	0.994
brca1	rnf8	ENSORLP00000005763	ENSORLP00000015004	Uncharacterized protein.	E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]	0.853
brca1	tp53bp1	ENSORLP00000005763	ENSORLP00000033455	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.998
mre11	Atm	ENSORLP00000009106	ENSORLP00000026266	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.963
mre11	brca1	ENSORLP00000009106	ENSORLP00000005763	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	Uncharacterized protein.	0.995