Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LOC101166150Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (198 aa)    
Predicted Functional Partners:
mapkapk5
MAPK activated protein kinase 5.
    
 0.999
LOC101159256
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 0.999
MAPKAPK2
MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.
    
 0.999
bag3
BCL2 associated athanogene 3.
   
 
 0.965
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity); Belongs to the p53 family.
    
 
 0.962
LOC101167464
Death-domain associated protein.
    
 
 0.960
eftud2
Elongation factor Tu GTP binding domain containing 2.
    
   0.914
sf3b3
Splicing factor 3b, subunit 3.
    
   0.898
huwe1
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1.
    
   0.869
hspb8
Heat shock protein b8; Belongs to the small heat shock protein (HSP20) family.
   
 
 0.834
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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