ifi30 protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ifi30

Si:dkey-197i20.6. (262 aa)

Predicted Functional Partners:

ccdc15

0.685

Wdr90

0.613

ENSORLP00000042816

0.613

auts2

0.606

LOC101175061

0.562

SCML2

0.562

ENSORLP00000041141

0.550

spag8

0.547

H2ML06_ORYLA

0.547

pacrg

0.547

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000041141	ENSORLP00000042816	ENSORLP00000041141	ENSORLP00000042816	Uncharacterized protein.	Uncharacterized protein.	0.830
ENSORLP00000041141	H2ML06_ORYLA	ENSORLP00000041141	ENSORLP00000019377	Uncharacterized protein.	Uncharacterized protein.	0.581
ENSORLP00000041141	Wdr90	ENSORLP00000041141	ENSORLP00000039753	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.830
ENSORLP00000041141	ifi30	ENSORLP00000041141	ENSORLP00000010465	Uncharacterized protein.	Si:dkey-197i20.6.	0.550
ENSORLP00000041141	pacrg	ENSORLP00000041141	ENSORLP00000035115	Uncharacterized protein.	PARK2 co-regulated.	0.792
ENSORLP00000041141	spag8	ENSORLP00000041141	ENSORLP00000017144	Uncharacterized protein.	Sperm associated antigen 8.	0.816
ENSORLP00000042816	ENSORLP00000041141	ENSORLP00000042816	ENSORLP00000041141	Uncharacterized protein.	Uncharacterized protein.	0.830
ENSORLP00000042816	H2ML06_ORYLA	ENSORLP00000042816	ENSORLP00000019377	Uncharacterized protein.	Uncharacterized protein.	0.723
ENSORLP00000042816	Wdr90	ENSORLP00000042816	ENSORLP00000039753	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.960
ENSORLP00000042816	ifi30	ENSORLP00000042816	ENSORLP00000010465	Uncharacterized protein.	Si:dkey-197i20.6.	0.613
ENSORLP00000042816	pacrg	ENSORLP00000042816	ENSORLP00000035115	Uncharacterized protein.	PARK2 co-regulated.	0.910
ENSORLP00000042816	spag8	ENSORLP00000042816	ENSORLP00000017144	Uncharacterized protein.	Sperm associated antigen 8.	0.830
H2ML06_ORYLA	ENSORLP00000041141	ENSORLP00000019377	ENSORLP00000041141	Uncharacterized protein.	Uncharacterized protein.	0.581
H2ML06_ORYLA	ENSORLP00000042816	ENSORLP00000019377	ENSORLP00000042816	Uncharacterized protein.	Uncharacterized protein.	0.723
H2ML06_ORYLA	Wdr90	ENSORLP00000019377	ENSORLP00000039753	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.723
H2ML06_ORYLA	ifi30	ENSORLP00000019377	ENSORLP00000010465	Uncharacterized protein.	Si:dkey-197i20.6.	0.547
H2ML06_ORYLA	pacrg	ENSORLP00000019377	ENSORLP00000035115	Uncharacterized protein.	PARK2 co-regulated.	0.581
H2ML06_ORYLA	spag8	ENSORLP00000019377	ENSORLP00000017144	Uncharacterized protein.	Sperm associated antigen 8.	0.581
LOC101175061	auts2	ENSORLP00000004495	ENSORLP00000044777	Scm polycomb group protein like 2.	Activator of transcription and developmental regulator AUTS2 a.	0.774
LOC101175061	ccdc15	ENSORLP00000004495	ENSORLP00000017933	Scm polycomb group protein like 2.	Coiled-coil domain containing 15.	0.831

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

0.000469

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016126

Sterol biosynthetic process

3 of 19

2.38

1.71

0.00062

GO:0008610

Lipid biosynthetic process

6 of 304

1.48

1.56

9.58e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.18

1.43

0.0027

GO:0006629

Lipid metabolic process

7 of 717

1.17

1.12

0.00023

GO:0051353

Positive regulation of oxidoreductase activity

2 of 16

2.28

0.84

0.0286

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016717

Oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

3 of 5

2.96

2.69

1.24e-05

GO:0005506

Iron ion binding

5 of 147

1.71

2.03

1.81e-05

GO:0016491

Oxidoreductase activity

9 of 735

1.27

1.76

7.05e-08

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

5 of 201

1.58

1.72

6.20e-05

GO:0000254

C-4 methylsterol oxidase activity

2 of 3

3.0

1.55

0.0016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005789

Endoplasmic reticulum membrane

5 of 518

1.17

0.82

0.0063

GO:0005783

Endoplasmic reticulum

6 of 815

1.05

0.76

0.0056

GO:0005737

Cytoplasm

11 of 6418

0.41

0.33

0.0063

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7252

Cytochrome P450 - arranged by substrate type, and Steroid biosynthetic process

8 of 138

1.94

4.42

5.66e-12

CL:7249

Mixed, incl. Cytochrome P450 - arranged by substrate type, and Short-chain dehydrogenase/reductase SDR

9 of 199

1.84

4.27

8.16e-13

CL:7431

Mixed, incl. Sterol biosynthetic process, and 3-beta-hydroxy-delta5-steroid dehydrogenase activity

5 of 39

2.29

3.74

2.85e-08

CL:7434

Mixed, incl. Fatty acid hydroxylase, and Steroid biosynthesis

4 of 22

2.44

3.22

6.26e-07

CL:7380

Electron transport from NADPH to Ferredoxin, and Fatty acid desaturase

3 of 5

2.96

2.94

4.21e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8957322

Metabolism of steroids

6 of 93

1.99

3.4

2.26e-08

MAP-556833

Metabolism of lipids

8 of 574

1.32

1.83

2.10e-07

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

3.0

1.6

0.0013

MAP-196108

Pregnenolone biosynthesis

2 of 7

2.64

1.33

0.0038

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 10

2.48

1.22

0.0058

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04116

Fatty acid hydroxylase

4 of 9

2.83

3.81

8.88e-08

PF00487

Fatty acid desaturase

2 of 4

2.88

1.35

0.0036

PF00111

2Fe-2S iron-sulfur cluster binding domain

2 of 6

2.7

1.29

0.0045

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006694

Fatty acid hydroxylase

4 of 9

2.83

3.55

2.76e-07

IPR001055

Adrenodoxin

2 of 2

3.18

1.3

0.0045

IPR005804

Fatty acid desaturase domain

2 of 4

2.88

1.18

0.0075

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

2 of 8

2.58

1.03

0.0135

IPR036010

2Fe-2S ferredoxin-like superfamily

2 of 7

2.64

1.03

0.0135

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 8

2.58

1.12

0.0091

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (20%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2024

Credits

Access

Info

About