Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
LOC101158107Rho guanine nucleotide exchange factor (GEF) 3, like. (495 aa)    
Predicted Functional Partners:
rrad
Ras-related associated with diabetes.
    
 0.708
akap12
A kinase (PRKA) anchor protein 12b.
      
 0.673
LOC101156944
RAS protein activator like 3.
   
  
 0.668
mier3
Mesoderm induction early response 1, family member 3 b.
      
 0.633
H2M6L5_ORYLA
Uncharacterized protein.
      
 0.535
ap2m1
AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]
    
 0.512
tmem104
Transmembrane protein 104.
      
 0.495
uimc1
Uncharacterized protein.
      
 0.489
LOC101171603
3'-phosphoadenosine 5'-phosphosulfate synthase 2a.
      
 0.485
ap2s1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
   
  0.478
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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