STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101172288Amyloid beta (A4) precursor protein b. (738 aa)    
Predicted Functional Partners:
sorl1
Sortilin-related receptor, L(DLR class) A repeats containing.
    
 0.914
NCSTN
Nicastrin.
    
 0.905
tnfrsf21
Tumor necrosis factor receptor superfamily, member 21.
    
 
 0.864
pitrm1
Pitrilysin metallopeptidase 1.
    
 
 0.845
LOC101161673
Apolipoprotein Eb.
    
 0.831
snca
Uncharacterized protein; Belongs to the synuclein family.
   
 0.767
LOC101157559
Insulin-degrading enzyme; Belongs to the peptidase M16 family.
    
 
 0.761
LOC101158223
Insulin-degrading enzyme; Belongs to the peptidase M16 family.
    
 
 0.761
psenen
Presenilin enhancer, gamma-secretase subunit.
    
 0.732
psen2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 
 0.727
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.