hgf protein (Oryzias latipes) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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hgf

Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (712 aa)

Predicted Functional Partners:

met

0.969

LOC101175393

0.799

mst1r

0.799

flt1

0.747

LOC101169984

0.721

egfr

0.721

ENSORLP00000027787

0.714

ntrk1

0.714

LOC101163560

0.713

LOC101173298

0.713

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSORLP00000027787	hgf	ENSORLP00000027787	ENSORLP00000012036	Neurotrophic tyrosine kinase, receptor, type 2b.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.714
LOC101163560	LOC101173298	ENSORLP00000029312	ENSORLP00000030267	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.903
LOC101163560	hgf	ENSORLP00000029312	ENSORLP00000012036	Tyrosine-protein kinase receptor.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.713
LOC101169984	LOC101175393	ENSORLP00000004470	ENSORLP00000004366	Receptor protein-tyrosine kinase.	Macrophage stimulating 1 receptor a.	0.757
LOC101169984	egfr	ENSORLP00000004470	ENSORLP00000022143	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.902
LOC101169984	hgf	ENSORLP00000004470	ENSORLP00000012036	Receptor protein-tyrosine kinase.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.721
LOC101169984	met	ENSORLP00000004470	ENSORLP00000024532	Receptor protein-tyrosine kinase.	MET proto-oncogene, receptor tyrosine kinase.	0.771
LOC101169984	mst1r	ENSORLP00000004470	ENSORLP00000034975	Receptor protein-tyrosine kinase.	Macrophage stimulating 1 receptor b.	0.757
LOC101173298	LOC101163560	ENSORLP00000030267	ENSORLP00000029312	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase receptor.	0.903
LOC101173298	hgf	ENSORLP00000030267	ENSORLP00000012036	Tyrosine-protein kinase receptor.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.713
LOC101175393	LOC101169984	ENSORLP00000004366	ENSORLP00000004470	Macrophage stimulating 1 receptor a.	Receptor protein-tyrosine kinase.	0.757
LOC101175393	egfr	ENSORLP00000004366	ENSORLP00000022143	Macrophage stimulating 1 receptor a.	Receptor protein-tyrosine kinase.	0.757
LOC101175393	hgf	ENSORLP00000004366	ENSORLP00000012036	Macrophage stimulating 1 receptor a.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.799
LOC101175393	met	ENSORLP00000004366	ENSORLP00000024532	Macrophage stimulating 1 receptor a.	MET proto-oncogene, receptor tyrosine kinase.	0.678
LOC101175393	mst1r	ENSORLP00000004366	ENSORLP00000034975	Macrophage stimulating 1 receptor a.	Macrophage stimulating 1 receptor b.	0.686
egfr	LOC101169984	ENSORLP00000022143	ENSORLP00000004470	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.902
egfr	LOC101175393	ENSORLP00000022143	ENSORLP00000004366	Receptor protein-tyrosine kinase.	Macrophage stimulating 1 receptor a.	0.757
egfr	hgf	ENSORLP00000022143	ENSORLP00000012036	Receptor protein-tyrosine kinase.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.721
egfr	met	ENSORLP00000022143	ENSORLP00000024532	Receptor protein-tyrosine kinase.	MET proto-oncogene, receptor tyrosine kinase.	0.771
egfr	mst1r	ENSORLP00000022143	ENSORLP00000034975	Receptor protein-tyrosine kinase.	Macrophage stimulating 1 receptor b.	0.757

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

10

PPI enrichment p-value:

1.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031204

Post-translational protein targeting to membrane, translocation

4 of 6

3.28

4.69

2.97e-09

GO:0045047

Protein targeting to ER

5 of 28

2.7

4.55

2.49e-09

GO:0006612

Protein targeting to membrane

5 of 51

2.44

4.16

6.70e-09

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

4 of 17

2.82

3.98

4.00e-08

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

3 of 5

3.23

3.36

8.22e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043022

Ribosome binding

4 of 61

2.27

2.52

1.25e-05

GO:0008320

Protein transmembrane transporter activity

2 of 13

2.64

1.13

0.0088

GO:0019838

Growth factor binding

2 of 18

2.5

1.12

0.0088

GO:0042562

Hormone binding

2 of 26

2.34

1.04

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140534

Endoplasmic reticulum protein-containing complex

7 of 74

2.43

6.44

3.60e-14

GO:0071256

Translocon complex

4 of 4

3.45

5.6

7.00e-11

GO:0005789

Endoplasmic reticulum membrane

11 of 581

1.73

4.5

1.14e-16

GO:0005784

Sec61 translocon complex

3 of 3

3.45

4.0

5.84e-08

GO:0008250

Oligosaccharyltransferase complex

3 of 10

2.93

3.38

6.25e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31634

Oligosaccharyltransferase complex, and Post-translational protein targeting to membrane, translocation

10 of 24

3.07

13.33

2.63e-26

CL:31636

Oligosaccharyltransferase complex, and Translocon-associated

8 of 18

3.1

10.68

7.22e-21

CL:31661

Mixed, incl. Sec61beta family, and Translocon-associated

5 of 5

3.45

6.95

2.28e-13

CL:31638

Oligosaccharyltransferase complex

3 of 11

2.89

5.12e-06

CL:31641

Oligosaccharyltransferase complex

2 of 5

3.05

1.68

0.00093

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

10 of 303

1.97

5.9

1.62e-17

map03060

Protein export

4 of 39

2.46

3.66

8.41e-08

map04145

Phagosome

4 of 151

1.87

2.29

1.03e-05

map00510

N-Glycan biosynthesis

2 of 71

1.9

0.99

0.0120

map00513

Various types of N-glycan biosynthesis

2 of 80

1.85

0.98

0.0121

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

6 of 115

2.17

4.09

1.80e-09

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

3 of 17

2.7

2.59

1.62e-05

MAP-72766

Translation

6 of 322

1.72

2.56

3.76e-07

MAP-9609507

Protein localization

3 of 210

1.61

0.87

0.0163

MAP-392499

Metabolism of proteins

6 of 2399

0.85

0.54

0.0181

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071256

Translocon complex

5 of 6

3.37

6.9

2.69e-13

GOCC:0005789

Endoplasmic reticulum membrane

9 of 199

2.11

6.09

7.43e-16

GOCC:0005784

Sec61 translocon complex

4 of 5

3.35

5.38

1.69e-10

GOCC:0005783

Endoplasmic reticulum

10 of 354

1.9

5.24

5.63e-16

GOCC:0098796

Membrane protein complex

8 of 516

1.64

3.15

1.69e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

4 of 61

2.27

2.93

1.65e-06

KW-0811

Translocation

2 of 13

2.64

1.72

0.00069

KW-1133

Transmembrane helix

10 of 6441

0.64

0.55

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03911

Sec61beta family

2 of 2

3.45

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030671

Protein transport Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

IPR016482

Protein transport protein SecG/Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

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