sppl3 protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

sppl3

Signal peptide peptidase 3. (383 aa)

Predicted Functional Partners:

apip

0.558

nagpa

0.558

slc35a1

0.492

SLC35A4

0.492

fam98a

0.485

ttc19

0.478

derl2

0.462

derl1

0.462

LOC101163550

0.440

sec63

0.436

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101163550	sppl3	ENSORLP00000029198	ENSORLP00000012111	Nodal modulator.	Signal peptide peptidase 3.	0.440
SLC35A4	sppl3	ENSORLP00000037759	ENSORLP00000012111	Solute carrier family 35 member A4.	Signal peptide peptidase 3.	0.492
apip	sppl3	ENSORLP00000001198	ENSORLP00000012111	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.	Signal peptide peptidase 3.	0.558
derl1	derl2	ENSORLP00000041992	ENSORLP00000015770	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.997
derl1	sec63	ENSORLP00000041992	ENSORLP00000028605	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	SEC63 homolog, protein translocation regulator.	0.697
derl1	sppl3	ENSORLP00000041992	ENSORLP00000012111	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Signal peptide peptidase 3.	0.462
derl2	derl1	ENSORLP00000015770	ENSORLP00000041992	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.997
derl2	sec63	ENSORLP00000015770	ENSORLP00000028605	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	SEC63 homolog, protein translocation regulator.	0.699
derl2	sppl3	ENSORLP00000015770	ENSORLP00000012111	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Signal peptide peptidase 3.	0.462
fam98a	sppl3	ENSORLP00000044105	ENSORLP00000012111	Uncharacterized protein.	Signal peptide peptidase 3.	0.485
nagpa	sppl3	ENSORLP00000019239	ENSORLP00000012111	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase.	Signal peptide peptidase 3.	0.558
sec63	derl1	ENSORLP00000028605	ENSORLP00000041992	SEC63 homolog, protein translocation regulator.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.697
sec63	derl2	ENSORLP00000028605	ENSORLP00000015770	SEC63 homolog, protein translocation regulator.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.699
sec63	sppl3	ENSORLP00000028605	ENSORLP00000012111	SEC63 homolog, protein translocation regulator.	Signal peptide peptidase 3.	0.436
slc35a1	sppl3	ENSORLP00000014269	ENSORLP00000012111	Uncharacterized protein.	Signal peptide peptidase 3.	0.492
sppl3	LOC101163550	ENSORLP00000012111	ENSORLP00000029198	Signal peptide peptidase 3.	Nodal modulator.	0.440
sppl3	SLC35A4	ENSORLP00000012111	ENSORLP00000037759	Signal peptide peptidase 3.	Solute carrier family 35 member A4.	0.492
sppl3	apip	ENSORLP00000012111	ENSORLP00000001198	Signal peptide peptidase 3.	Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.	0.558
sppl3	derl1	ENSORLP00000012111	ENSORLP00000041992	Signal peptide peptidase 3.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.462
sppl3	derl2	ENSORLP00000012111	ENSORLP00000015770	Signal peptide peptidase 3.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.462