STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pax6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development; Belongs to the paired homeobox family. (457 aa)    
Predicted Functional Partners:
TIMM22
Translocase of inner mitochondrial membrane 22.
    
 0.751
six3
Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...]
   
 
 0.699
hras
HRas proto-oncogene, GTPase a.
   
 
 0.699
six3-2
Homeobox protein SIX3.
   
 
 0.698
LOC101157139
Retinal outer segment membrane protein 1b.
      
 0.678
Timm9
zf-Tim10_DDP domain-containing protein.
   
 
 0.677
timm10
Translocase of inner mitochondrial membrane 10 homolog (yeast).
   
 0.638
vax1
Ventral anterior homeobox 1.
    
 
0.636
meis2
Meis homeobox 2a.
   
 
 0.629
shh
Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.
   
  
 0.625
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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