STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spdl1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family. (573 aa)    
Predicted Functional Partners:
cdc20
WD_REPEATS_REGION domain-containing protein.
   
 
  0.641
cdc20b
WD_REPEATS_REGION domain-containing protein.
   
 
  0.641
ska1
Spindle and kinetochore associated complex subunit 1.
   
 
  0.616
ect2
Epithelial cell transforming 2.
  
    0.590
ska3
Spindle and kinetochore associated complex subunit 3.
   
 
  0.583
plk4
Polo-like kinase 4 (Drosophila).
   
 
 0.541
ska2
SKA2 domain-containing protein.
     
  0.540
plk2
Serine/threonine-protein kinase PLK.
   
 
  0.526
plk3
Serine/threonine-protein kinase PLK.
   
 
  0.526
PLK1
Serine/threonine-protein kinase PLK.
   
 
  0.526
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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