LOC101169846 protein (Oryzias latipes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC101169846

Uncharacterized protein. (990 aa)

Predicted Functional Partners:

LOC101160196

0.640

efnb1

0.640

H2M6E4_ORYLA

0.636

LOC101165932

0.636

ENSORLP00000034742

0.636

ENSORLP00000036645

0.636

ENSORLP00000041578

0.636

LOC101159120

0.589

EFNA5

0.589

LOC101172801

0.581

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EFNA5	LOC101160196	ENSORLP00000040245	ENSORLP00000004588	Ephrin A5; Belongs to the ephrin family.	Ephrin-B3a; Belongs to the ephrin family.	0.770
EFNA5	LOC101169846	ENSORLP00000040245	ENSORLP00000013810	Ephrin A5; Belongs to the ephrin family.	Uncharacterized protein.	0.589
EFNA5	LOC101172801	ENSORLP00000040245	ENSORLP00000006352	Ephrin A5; Belongs to the ephrin family.	Ephrin RBD domain-containing protein; Belongs to the ephrin family.	0.560
EFNA5	efnb1	ENSORLP00000040245	ENSORLP00000044641	Ephrin A5; Belongs to the ephrin family.	Ephrin-B1; Belongs to the ephrin family.	0.674
ENSORLP00000034742	ENSORLP00000036645	ENSORLP00000034742	ENSORLP00000036645	Uncharacterized protein.	EH domain-containing protein.	0.962
ENSORLP00000034742	ENSORLP00000041578	ENSORLP00000034742	ENSORLP00000041578	Uncharacterized protein.	SH3 domain-containing protein.	0.962
ENSORLP00000034742	H2M6E4_ORYLA	ENSORLP00000034742	ENSORLP00000014038	Uncharacterized protein.	Uncharacterized protein.	0.995
ENSORLP00000034742	LOC101165932	ENSORLP00000034742	ENSORLP00000020940	Uncharacterized protein.	Intersectin 2a.	0.962
ENSORLP00000034742	LOC101169846	ENSORLP00000034742	ENSORLP00000013810	Uncharacterized protein.	Uncharacterized protein.	0.636
ENSORLP00000036645	ENSORLP00000034742	ENSORLP00000036645	ENSORLP00000034742	EH domain-containing protein.	Uncharacterized protein.	0.962
ENSORLP00000036645	ENSORLP00000041578	ENSORLP00000036645	ENSORLP00000041578	EH domain-containing protein.	SH3 domain-containing protein.	0.962
ENSORLP00000036645	H2M6E4_ORYLA	ENSORLP00000036645	ENSORLP00000014038	EH domain-containing protein.	Uncharacterized protein.	0.962
ENSORLP00000036645	LOC101165932	ENSORLP00000036645	ENSORLP00000020940	EH domain-containing protein.	Intersectin 2a.	0.962
ENSORLP00000036645	LOC101169846	ENSORLP00000036645	ENSORLP00000013810	EH domain-containing protein.	Uncharacterized protein.	0.636
ENSORLP00000041578	ENSORLP00000034742	ENSORLP00000041578	ENSORLP00000034742	SH3 domain-containing protein.	Uncharacterized protein.	0.962
ENSORLP00000041578	ENSORLP00000036645	ENSORLP00000041578	ENSORLP00000036645	SH3 domain-containing protein.	EH domain-containing protein.	0.962
ENSORLP00000041578	H2M6E4_ORYLA	ENSORLP00000041578	ENSORLP00000014038	SH3 domain-containing protein.	Uncharacterized protein.	0.962
ENSORLP00000041578	LOC101165932	ENSORLP00000041578	ENSORLP00000020940	SH3 domain-containing protein.	Intersectin 2a.	0.962
ENSORLP00000041578	LOC101169846	ENSORLP00000041578	ENSORLP00000013810	SH3 domain-containing protein.	Uncharacterized protein.	0.636
H2M6E4_ORYLA	ENSORLP00000034742	ENSORLP00000014038	ENSORLP00000034742	Uncharacterized protein.	Uncharacterized protein.	0.995

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.962

expected number of edges:

10

PPI enrichment p-value:

1.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031204

Post-translational protein targeting to membrane, translocation

4 of 6

3.28

4.69

2.97e-09

GO:0045047

Protein targeting to ER

5 of 28

2.7

4.55

2.49e-09

GO:0006612

Protein targeting to membrane

5 of 51

2.44

4.16

6.70e-09

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

4 of 17

2.82

3.98

4.00e-08

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

3 of 5

3.23

3.36

8.22e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043022

Ribosome binding

4 of 61

2.27

2.52

1.25e-05

GO:0008320

Protein transmembrane transporter activity

2 of 13

2.64

1.13

0.0088

GO:0019838

Growth factor binding

2 of 18

2.5

1.12

0.0088

GO:0042562

Hormone binding

2 of 26

2.34

1.04

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140534

Endoplasmic reticulum protein-containing complex

7 of 74

2.43

6.44

3.60e-14

GO:0071256

Translocon complex

4 of 4

3.45

5.6

7.00e-11

GO:0005789

Endoplasmic reticulum membrane

11 of 581

1.73

4.5

1.14e-16

GO:0005784

Sec61 translocon complex

3 of 3

3.45

4.0

5.84e-08

GO:0008250

Oligosaccharyltransferase complex

3 of 10

2.93

3.38

6.25e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:31634

Oligosaccharyltransferase complex, and Post-translational protein targeting to membrane, translocation

10 of 24

3.07

13.33

2.63e-26

CL:31636

Oligosaccharyltransferase complex, and Translocon-associated

8 of 18

3.1

10.68

7.22e-21

CL:31661

Mixed, incl. Sec61beta family, and Translocon-associated

5 of 5

3.45

6.95

2.28e-13

CL:31638

Oligosaccharyltransferase complex

3 of 11

2.89

5.12e-06

CL:31641

Oligosaccharyltransferase complex

2 of 5

3.05

1.68

0.00093

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04141

Protein processing in endoplasmic reticulum

10 of 303

1.97

5.9

1.62e-17

map03060

Protein export

4 of 39

2.46

3.66

8.41e-08

map04145

Phagosome

4 of 151

1.87

2.29

1.03e-05

map00510

N-Glycan biosynthesis

2 of 71

1.9

0.99

0.0120

map00513

Various types of N-glycan biosynthesis

2 of 80

1.85

0.98

0.0121

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

6 of 115

2.17

4.09

1.80e-09

MAP-9609523

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

3 of 17

2.7

2.59

1.62e-05

MAP-72766

Translation

6 of 322

1.72

2.56

3.76e-07

MAP-9609507

Protein localization

3 of 210

1.61

0.87

0.0163

MAP-392499

Metabolism of proteins

6 of 2399

0.85

0.54

0.0181

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071256

Translocon complex

5 of 6

3.37

6.9

2.69e-13

GOCC:0005789

Endoplasmic reticulum membrane

9 of 199

2.11

6.09

7.43e-16

GOCC:0005784

Sec61 translocon complex

4 of 5

3.35

5.38

1.69e-10

GOCC:0005783

Endoplasmic reticulum

10 of 354

1.9

5.24

5.63e-16

GOCC:0098796

Membrane protein complex

8 of 516

1.64

3.15

1.69e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0256

Endoplasmic reticulum

4 of 61

2.27

2.93

1.65e-06

KW-0811

Translocation

2 of 13

2.64

1.72

0.00069

KW-1133

Transmembrane helix

10 of 6441

0.64

0.55

0.00019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03911

Sec61beta family

2 of 2

3.45

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030671

Protein transport Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

IPR016482

Protein transport protein SecG/Sec61-beta/Sbh

2 of 2

3.45

1.37

0.0035

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2024

Credits

Access

Info

About