LOC101169975 protein (Oryzias latipes) - STRING interaction network

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Predicted Interactions

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Score

LOC101169975

FATP synthase c subunit lysine N-methyltransferase. (231 aa)

Predicted Functional Partners:

fau

0.625

trmt112

0.597

mettl18

0.563

eef1akmt2

0.561

eef2kmt

0.560

mettl21a

0.559

LOC101157982

0.559

vcpkmt

0.558

etfbkmt

0.558

mettl23

0.558

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC101157982	LOC101169975	ENSORLP00000044675	ENSORLP00000016029	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	FATP synthase c subunit lysine N-methyltransferase.	0.559
LOC101157982	eef1akmt2	ENSORLP00000044675	ENSORLP00000007077	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	0.683
LOC101157982	eef2kmt	ENSORLP00000044675	ENSORLP00000027758	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	Eukaryotic elongation factor 2 lysine methyltransferase.	0.558
LOC101157982	etfbkmt	ENSORLP00000044675	ENSORLP00000020532	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	Electron transfer flavoprotein subunit beta lysine methyltransferase.	0.559
LOC101157982	mettl18	ENSORLP00000044675	ENSORLP00000042377	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	Methyltransferase like 18.	0.606
LOC101157982	mettl21a	ENSORLP00000044675	ENSORLP00000002888	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	Methyltransferase like 21A.	0.666
LOC101157982	mettl23	ENSORLP00000044675	ENSORLP00000027483	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	Methyltransferase like 23.	0.493
LOC101157982	vcpkmt	ENSORLP00000044675	ENSORLP00000020194	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	Valosin containing protein lysine (K) methyltransferase.	0.558
LOC101169975	LOC101157982	ENSORLP00000016029	ENSORLP00000044675	FATP synthase c subunit lysine N-methyltransferase.	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	0.559
LOC101169975	eef1akmt2	ENSORLP00000016029	ENSORLP00000007077	FATP synthase c subunit lysine N-methyltransferase.	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	0.561
LOC101169975	eef2kmt	ENSORLP00000016029	ENSORLP00000027758	FATP synthase c subunit lysine N-methyltransferase.	Eukaryotic elongation factor 2 lysine methyltransferase.	0.560
LOC101169975	etfbkmt	ENSORLP00000016029	ENSORLP00000020532	FATP synthase c subunit lysine N-methyltransferase.	Electron transfer flavoprotein subunit beta lysine methyltransferase.	0.558
LOC101169975	fau	ENSORLP00000016029	ENSORLP00000018903	FATP synthase c subunit lysine N-methyltransferase.	40S ribosomal protein S30.	0.625
LOC101169975	mettl18	ENSORLP00000016029	ENSORLP00000042377	FATP synthase c subunit lysine N-methyltransferase.	Methyltransferase like 18.	0.563
LOC101169975	mettl21a	ENSORLP00000016029	ENSORLP00000002888	FATP synthase c subunit lysine N-methyltransferase.	Methyltransferase like 21A.	0.559
LOC101169975	mettl23	ENSORLP00000016029	ENSORLP00000027483	FATP synthase c subunit lysine N-methyltransferase.	Methyltransferase like 23.	0.558
LOC101169975	trmt112	ENSORLP00000016029	ENSORLP00000002920	FATP synthase c subunit lysine N-methyltransferase.	tRNA methyltransferase subunit 11-2.	0.597
LOC101169975	vcpkmt	ENSORLP00000016029	ENSORLP00000020194	FATP synthase c subunit lysine N-methyltransferase.	Valosin containing protein lysine (K) methyltransferase.	0.558
eef1akmt2	LOC101157982	ENSORLP00000007077	ENSORLP00000044675	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.	0.683
eef1akmt2	LOC101169975	ENSORLP00000007077	ENSORLP00000016029	EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.	FATP synthase c subunit lysine N-methyltransferase.	0.561

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Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.414

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0060070

Canonical Wnt signaling pathway

3 of 81

1.9

0.9

0.0189

GO:0016055

Wnt signaling pathway

4 of 216

1.6

0.85

0.0185

GO:0090090

Negative regulation of canonical Wnt signaling pathway

3 of 98

1.82

0.83

0.0247

GO:0046849

Bone remodeling

2 of 14

2.49

0.83

0.0304

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071936

Coreceptor activity involved in Wnt signaling pathway

2 of 2

3.33

1.39

0.0031

GO:0039706

Co-receptor binding

2 of 7

2.79

1.12

0.0094

GO:0048019

Receptor antagonist activity

2 of 9

2.68

1.11

0.0095

GO:0042813

Wnt receptor activity

2 of 18

2.38

0.93

0.0197

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071821

FANCM-MHF complex

2 of 5

2.93

1.26

0.0052

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37339990

(2023) TGFbeta inhibition and mesenchymal to epithelial transition initiation by Xenopus egg extract: first steps towards early reprogramming in fish somatic cell.

3 of 42

2.19

1.18

0.0061

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21213

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

4 of 6

3.16

4.15

2.70e-08

CL:21106

Wnt signaling pathway, and Negative regulation of TCF-dependent signaling by WNT ligand antagonists

5 of 61

2.25

3.36

1.69e-07

CL:1161

Mixed, incl. Centromere complex assembly, and Carbohydrate-binding WSC

2 of 16

2.43

0.94

0.0190

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ola04310

Wnt signaling pathway

3 of 180

1.55

0.91

0.0120

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3772470

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

5 of 12

2.95

5.44

7.75e-11

MAP-201681

TCF dependent signaling in response to WNT

5 of 258

1.62

1.77

6.00e-05

MAP-195721

Signaling by WNT

5 of 413

1.41

1.33

0.00040

MAP-4641263

Regulation of FZD by ubiquitination

2 of 22

2.29

0.95

0.0180

MAP-162582

Signal Transduction

9 of 4038

0.68

0.53

0.0021

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990851

Wnt-Frizzled-LRP5/6 complex

2 of 2

3.33

1.53

0.0018

GOCC:0071821

FANCM-MHF complex

2 of 5

2.93

1.52

0.0018

GOCC:0098797

Plasma membrane protein complex

5 of 479

1.35

1.09

0.0018

GOCC:0098796

Membrane protein complex

6 of 1010

1.11

0.9

0.0018

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01822

WSC domain

2 of 2

3.33

1.43

0.0027

PF04706

Dickkopf N-terminal cysteine-rich region

2 of 6

2.85

1.22

0.0063

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002889

Carbohydrate-binding WSC

3 of 3

3.33

2.75

1.08e-05

IPR039863

Dickkopf-like protein

2 of 6

2.85

0.94

0.0198

IPR006796

Dickkopf, N-terminal cysteine-rich

2 of 6

2.85

0.94

0.0198

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