STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hsc70Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (700 aa)    
Predicted Functional Partners:
gak
Cyclin G associated kinase.
    
 0.882
LOC101169506
Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.
 
 
 0.879
stip1
Stress-induced phosphoprotein 1.
  
 0.847
dnaja2
DnaJ heat shock protein family (Hsp40) member A2.
 
 0.847
dnajc6
DnaJ (Hsp40) homolog, subfamily C, member 6.
    
 0.829
dnajb4
DnaJ heat shock protein family (Hsp40) member B4.
 
 0.811
LOC101175395
DnaJ heat shock protein family (Hsp40) member A2b.
 
 0.810
hsp90ab1
Heat shock protein 90, alpha (cytosolic), class B member 1.
 
 
 0.810
LOC101162427
DnaJ heat shock protein family (Hsp40) member A1.
 
 0.809
DNAJA4
Uncharacterized protein.
 
 0.807
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.