STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
siah1E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (286 aa)    
Predicted Functional Partners:
cacybp
Calcyclin binding protein.
    
 0.982
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 0.946
LOC101171502
Uncharacterized protein.
    
 0.929
rad18
RAD18 E3 ubiquitin protein ligase.
      
 0.718
H2MG95_ORYLA
Ring-box 1, E3 ubiquitin protein ligase.
      
 0.676
pex12
Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.
      
 0.659
snca
Uncharacterized protein; Belongs to the synuclein family.
    
 0.655
ENSORLP00000026261
UBIQUITIN_CONJUGAT_2 domain-containing protein.
    
   0.638
ube2v2
Ubiquitin-conjugating enzyme E2 variant 2.
    
   0.638
ube2n
Ubiquitin-conjugating enzyme E2Nb; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.622
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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