STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
atoh7Atonal bHLH transcription factor 7. (142 aa)    
Predicted Functional Partners:
pou4f2
POU domain protein.
      
 0.646
vsx2
Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina (By similarity). Belongs to the paired homeobox family.
   
  
 0.638
LOC101168145
Visual system homeobox 1 homolog, chx10-like.
   
  
 0.619
six3
Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...]
   
  
 0.552
six3-2
Homeobox protein SIX3.
   
  
 0.551
afap1
Actin filament associated protein 1.
      
 0.509
txnrd2
Thioredoxin reductase 2, tandem duplicate 1.
      
 0.509
foxn4
Forkhead box N4.
   
  
 0.499
LOC101175530
Uncharacterized protein.
   
  
 0.477
gdf11
Growth differentiation factor 11.
   
  
 0.475
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.