STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egr2Early growth response 2b. (449 aa)    
Predicted Functional Partners:
egr3
Uncharacterized protein.
  
 
0.971
LOC101164744
Uncharacterized protein.
  
 
 
0.905
LOC101165801
NGFI-A binding protein 2 (EGR1 binding protein 2).
   
 0.875
fosb
FBJ murine osteosarcoma viral oncogene homolog B.
   
 0.790
c-fos
BZIP domain-containing protein.
   
 0.744
egr1
Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.
  
 
0.724
sox10
SRY-box containing gene 10b.
    
 0.683
nab1
NGFI-A binding protein 1a (EGR1 binding protein 1).
    
 0.681
LOC101155601
CCAAT enhancer binding protein beta.
    
 0.596
sox9
HMG box domain-containing protein.
    
 0.593
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.