STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hps4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (616 aa)    
Predicted Functional Partners:
hps1
HPS1 biogenesis of lysosomal organelles complex 3 subunit 1.
    
 0.986
HPS6
HPS6 biogenesis of lysosomal organelles complex 2 subunit 3.
     
 0.928
bloc1s3
Biogenesis of lysosomal organelles complex-1, subunit 3.
     
 0.893
hps5
Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.
     
 0.892
dtnbp1
Dystrobrevin binding protein 1b.
     
 0.878
hps3
HPS3 biogenesis of lysosomal organelles complex 2 subunit 1.
      
 0.857
bloc1s6
Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]
     
 0.787
RAB38
RAB38, member RAS oncogene family.
     
 0.716
ap3b1
AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.
      
 0.672
bloc1s5
Biogenesis of lysosomal organelles complex-1, subunit 5, muted.
     
 0.606
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.