STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN14Protein tyrosine phosphatase non-receptor type 14. (1266 aa)    
Predicted Functional Partners:
yap1
Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (By similarity). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation.
   
 
 0.764
klhl6
Kelch-like family member 6.
      
 0.665
wwc3
WWC family member 3.
    
 
 0.576
clcn3
Chloride channel protein.
    
 
 0.576
clcn5
Chloride channel protein.
    
 
 0.576
ctnnb1
Catenin (cadherin-associated protein), beta 1.
    
 
 0.538
ptpn23
Protein tyrosine phosphatase, non-receptor type 23, a.
   
0.507
grb2
Growth factor receptor-bound protein 2b.
   
 0.490
angptl4
Angiopoietin-like 4.
    
 0.478
rapgef2
Rap guanine nucleotide exchange factor (GEF) 2.
    
   0.467
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.