hsbp1 protein (Oryzias latipes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

hsbp1

Heat shock factor binding protein 1a. (78 aa)

Predicted Functional Partners:

washc3

0.923

hspa4l

0.721

hsf4

0.700

hsf2

0.700

HSF1

0.700

hspa14

0.698

LOC100125490

0.677

pdxdc1

0.644

LOC101169506

0.614

hsp90ab1

0.614

Your Current Organism:

Oryzias latipes

NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSF1	LOC100125490	ENSORLP00000044922	ENSORLP00000027024	Heat shock transcription factor 1.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.651
HSF1	LOC101169506	ENSORLP00000044922	ENSORLP00000014900	Heat shock transcription factor 1.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.787
HSF1	hsbp1	ENSORLP00000044922	ENSORLP00000019773	Heat shock transcription factor 1.	Heat shock factor binding protein 1a.	0.700
HSF1	hsp90ab1	ENSORLP00000044922	ENSORLP00000033219	Heat shock transcription factor 1.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.787
HSF1	hspa14	ENSORLP00000044922	ENSORLP00000015785	Heat shock transcription factor 1.	Heat shock protein 14; Belongs to the heat shock protein 70 family.	0.431
HSF1	hspa4l	ENSORLP00000044922	ENSORLP00000019978	Heat shock transcription factor 1.	Heat shock protein 4 like.	0.498
LOC100125490	HSF1	ENSORLP00000027024	ENSORLP00000044922	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock transcription factor 1.	0.651
LOC100125490	LOC101169506	ENSORLP00000027024	ENSORLP00000014900	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	0.902
LOC100125490	hsbp1	ENSORLP00000027024	ENSORLP00000019773	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock factor binding protein 1a.	0.677
LOC100125490	hsf2	ENSORLP00000027024	ENSORLP00000019407	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock transcription factor 2.	0.651
LOC100125490	hsf4	ENSORLP00000027024	ENSORLP00000017264	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock transcription factor 4.	0.651
LOC100125490	hsp90ab1	ENSORLP00000027024	ENSORLP00000033219	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.810
LOC100125490	hspa14	ENSORLP00000027024	ENSORLP00000015785	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock protein 14; Belongs to the heat shock protein 70 family.	0.407
LOC100125490	hspa4l	ENSORLP00000027024	ENSORLP00000019978	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock protein 4 like.	0.737
LOC101169506	HSF1	ENSORLP00000014900	ENSORLP00000044922	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock transcription factor 1.	0.787
LOC101169506	LOC100125490	ENSORLP00000014900	ENSORLP00000027024	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.902
LOC101169506	hsbp1	ENSORLP00000014900	ENSORLP00000019773	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock factor binding protein 1a.	0.614
LOC101169506	hsf2	ENSORLP00000014900	ENSORLP00000019407	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock transcription factor 2.	0.787
LOC101169506	hsf4	ENSORLP00000014900	ENSORLP00000017264	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock transcription factor 4.	0.787
LOC101169506	hsp90ab1	ENSORLP00000014900	ENSORLP00000033219	Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2.	Heat shock protein 90, alpha (cytosolic), class B member 1.	0.946

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.814

expected number of edges:

31

PPI enrichment p-value:

0.42

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009102

Biotin biosynthetic process

4 of 6

2.29

2.43

2.01e-05

GO:0072330

Monocarboxylic acid biosynthetic process

5 of 30

1.68

1.98

2.19e-05

GO:0046394

Carboxylic acid biosynthetic process

6 of 107

1.21

1.17

0.00022

GO:0044281

Small molecule metabolic process

7 of 429

0.67

0.46

0.0126

GO:0071704

Organic substance metabolic process

10 of 1181

0.39

0.28

0.0258

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36584052

(2022) The inside scoop: Comparative genomics of two intranuclear bacteria, Candidatus Berkiella cookevillensis and Candidatus Berkiella aquae.

4 of 114

1.01

0.78

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1111

Biotin metabolic process

4 of 5

2.37

2.7

6.44e-06

CL:1034

Mixed, incl. Vitamin biosynthetic process, and Coenzyme A metabolic process

5 of 45

1.51

1.59

9.73e-05

CL:842

Small molecule biosynthetic process, and Nucleotide biosynthetic process

6 of 141

1.09

0.97

0.00055

CL:1311

Phosphopantetheine, and Fatty acid synthase activity

2 of 5

2.06

0.85

0.0254

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00780

Biotin metabolism

5 of 26

1.75

2.32

3.19e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0093

Biotin biosynthesis

2 of 3

2.29

0.9

0.0221

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