STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mlh3MutL homolog 3 (E. coli). (1125 aa)    
Predicted Functional Partners:
mlh1
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).
    
0.998
msh2
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 0.971
msh6
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
  
 0.971
msh5
MutS homolog 5.
 
 0.952
msh3
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.951
msh4
DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).
 
 0.951
pms1
PMS1 homolog 1, mismatch repair system component.
  
 
0.867
pms2
PMS1 homolog 2, mismatch repair system component.
    
0.864
exo1
Exonuclease 1.
   
 0.862
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
   
 0.833
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.