STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egfrReceptor protein-tyrosine kinase. (1185 aa)    
Predicted Functional Partners:
egf
Epidermal growth factor.
   
 0.991
grb2
Growth factor receptor-bound protein 2b.
    
 0.983
LOC101166137
EGF-like domain-containing protein.
    
 0.979
cbl
Cbl proto-oncogene, E3 ubiquitin protein ligase.
    
 0.974
LOC101155207
Betacellulin, epidermal growth factor family member.
    
 0.970
LOC101163758
Uncharacterized protein.
    
 0.969
cblb
Cbl proto-oncogene B, E3 ubiquitin protein ligase.
    
 0.969
SHC3
SHC adaptor protein 3.
    
 0.968
shc1
SHC (Src homology 2 domain containing) transforming protein 1.
    
 0.968
SHC4
SHC adaptor protein 4.
    
 0.968
Your Current Organism:
Oryzias latipes
NCBI taxonomy Id: 8090
Other names: Japanese medaka, Japanese rice fish, O. latipes, Poecilia latipes, medaka
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.